Research Funded by Ataxia UK
Ataxia UK funds a wide variety of research projects. Below is a list of all projects currently being funded, and of projects that have ended in the last few years.
Friedreich's Ataxia
| Project | Principal Researchers & Institution | Funders & Awards |
| Etravirine as a potential therapeutic for Friedreich's ataxia
|
Dr Alessandra Rufini, Fratagene Therapeutics, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome (Italy) | Research project grant
Award: £20,000 Funders: Ataxia UK |
| Development of a selective high throughput screening assay for the discovery of compounds replacing frataxin in FA | Dr Benoit D'Autréaux, Institute for Integrative Biology of the Cell, CNRS-CEA-Université Paris-Saclay Cell Biology department, Paris (France) | Research project grant
Award: £26,000 Funders: Ataxia UK
|
| Investigating the role of bioactive sphingolipids in Friedreich's ataxia | Dr Sara Anjomani Virmouni, Division of Biosciences, Brunel University, London (UK) | Research project grant
Award: £26,471 |
| Non-invasive transcranial cerebella stimulation: double blind, randomised, sham-controlled study followed by an open label extension phase | Dr Barbara Borroni, Department of Clinical and Experimental Sciences, University of Brescia, Brescia (Italy) | Research project grant
Award: £25,000 Funders: Ataxia UK |
| Molecular mechanisms of R-loop-mediated frataxin gene silencing | Dr Natalia Gromak, Sir William Dunn School of Pathology, University of Oxford (UK) | Research project grant
Award: £35,000 Funders: Ataxia UK |
| Generating new Freidreich's ataxia models for validating HSV-1 FXN gene therapy in Dorsal Root Ganglia | Dr Filip Lim, Department of Molecular Biology, Universidad Autonoma de Madrid (Spain) | Research project grant
Award: £60,000 Funders: Ataxia UK |
| European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) | Massimo Pandolfo, Université Libre de Bruxelles (ULB), Brussels (Belgium), Jörg B. Schulz, University Hospital RWTH Aachen, (Germany), Paola Giunti University College London (London, UK), Alexandra Dürr, UPMC Université Paris (France), Mathieu Anheim, Hôpitaux niversitaires de Strasbourg (France), Sylvia Boesch, Medical University Innsbruck (Austria), Caterina Mariotti, Fondazione IRCCS Istituto Neurologico “C.Besta” (Italy), Enrico Bertini, Bambino Gesù Children’s Research Hospital (Italy), Francesc Palau, Pediatric Institute for Rare Diseases – IPER (Spain) |
Research project grant
Award: £174,600 Funders: Ataxia UK, AFAF, Ataxia |
Cerebellar ataxia
| Project | Principal Researchers & Institution | Funders & Awards |
| Motor and cognitive outcomes of non-invasive transcranial alternate current stimulation by entrainment of cerebellar oscillations | Dr Barbara Borroni, Department of Clinical and Experimental Sciences, University of Brescia, Brescia (Italy) | Research project small grant
Award: £5,000 Funders: Ataxia UK |
| PROSPAX: an integrated multimodal progression chart in spastic ataxias |
Professor Rita Horvath, Department of Clinical Neurosciences, University of Cambridge (UK) | Research project small grant
Award: £5,000 Funders: Ataxia UK |
| Non-invasive transcranial cerebellar stimulation: double blind, randomised, sham-controlled study followed by an open label extension phase | Dr Barbara Borroni, Department of Clinical and Experimental Sciences, University of Brescia, Brescia (Italy) | Research project grant
Award: £25,000 Funders: Ataxia UK |
| Regulation of alternative splicing of voltage-gated Ca2+ channels by CRISPR/Cas9-mediated genome editing as potential genetic therapy for episodic ataxia type 2 | Dr Lorenzo Cingolani, Center for Synaptic Neuroscience (NSYN), Fondazione Istituto Italiano di Tecnologia (IIT), Genoa (Italy) | Research project small grant
Award: £5,000 Funders: Ataxia UK |
| Modelling SCA11 in cultured cells using CRISPR/Cas9 | Dr Mariana Santos Moreda Graca, Institute for Molecular and Cell Biology (IBMC), Porto (Portugal) | Research project small grant
Award: £5,000 Funders: Ataxia UK |
| Modelling the molecular pathogenesis of ARSACS with patient cells: disrupted proteostasis in ARSACS neurons | Professor Paul Chapple, Queen Mary University of London & Professor Michael Cheetham, University College London (London, UK) |
Research project grant
Award: £70,000 Funders: Ataxia UK, The ARSACS Foundation |
| Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK | Dr Clévio David Rodrigues Nóbrega, Universidade do Algarve (Portugal) | Research project grant
Award: £9,500 Funders: Ataxia UK |
| DNA repair pathways underlie common genetic mechanisms that modulate onset in spinocerebellar ataxias and other inherited ataxias | Dr Conceicao Bettencourt, Prof Henry Houlden, Prof Wood & Prof Giunti, Institute of Neurology, University College London (London, UK) |
PhD studentship grant
Award: £70,000 Funders: Ataxia UK, ACAH, R+SCAs, UCL Impact PhD Studentship Scheme |
| Development of a PRIME editing therapy for Ataxia-8 due to the c.121 A to T point mutation
|
Prof Jacques Tremblay, Department of Molecular Medicine, Faculty of Medicine, Laval University (Canada) | Research project grant
Award: £34,600 Funders: Ataxia UK and restricted donation from DVS foundation |
| Assessment of ataxia severity under real-life conditions with SARAhome: A multicenter study in spinocerebellar ataxia type 3 (SCA3) | Dr Marcus Grobe-Einsler and Prof Thomas Klockgether, German Center for Neurodegenerative Diseases (DZNE), Bonn (Germany)
|
Research project grant
Award: $80,000 Funders: Ataxia UK and NAF |
| A joint model of online SLT intervention and peer support to enhance communication effectiveness and participation in people with progressive ataxia | Prof Anja Lowit & Mrs Catherine McGee, Strathclyde University & NHS Greater Glasgow and Clyde (UK) | Research project small grant
Award: £5,997 Funders: Ataxia UK |
| NKX6-2 Related Spastic Ataxia and Leukodystrophy: Natural history, biomarkers and the potential of gene transfer methods |
Dr Viorica Chelban and Prof Henry Houlden, UCL Institute of Neurology, Queen Square, London (UK) |
Research project grant
Award: £69,988.29 Funders: Ataxia UK and restricted donation from DVS foundation
|
For information on Ataxia UK funded research that has ended in the last few years, click here.
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