Research Funded by Ataxia UK – Ataxia

Research Funded By Ataxia UK

Research Funded by Ataxia UK

Ataxia UK funds a wide variety of research projects. Below is a list of all projects currently being funded, and of projects that have ended in the last few years.

Friedreich's Ataxia

Project Principal Researchers & Institution Funders & Awards
Etravirine as a potential therapeutic for Friedreich's ataxia

 

Dr Alessandra Rufini, Fratagene Therapeutics, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome (Italy) Research project grant

Award: £20,000

Funders: Ataxia UK

Development of a selective high throughput screening assay for the discovery of compounds replacing frataxin in FA Dr Benoit D'Autréaux, Institute for Integrative Biology of the Cell, CNRS-CEA-Université Paris-Saclay Cell Biology department, Paris (France) Research project grant

Award: £26,000

Funders: Ataxia UK

 

Investigating the role of bioactive sphingolipids in Friedreich's ataxia Dr Sara Anjomani Virmouni, Division of Biosciences, Brunel University, London (UK) Research project grant

Award: £26,471

Non-invasive transcranial cerebella stimulation: double blind, randomised, sham-controlled study followed by an open label extension phase Dr Barbara Borroni, Department of Clinical and Experimental Sciences, University of Brescia, Brescia (Italy) Research project grant

Award: £25,000

Funders: Ataxia UK

Molecular mechanisms of R-loop-mediated frataxin gene silencing Dr Natalia Gromak, Sir William Dunn School of Pathology, University of Oxford (UK) Research project grant

Award: £35,000

Funders: Ataxia UK

Generating new Freidreich's ataxia models for validating HSV-1 FXN gene therapy in Dorsal Root Ganglia Dr Filip Lim, Department of Molecular Biology, Universidad Autonoma de Madrid (Spain) Research project grant

Award: £60,000

Funders: Ataxia UK

European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) Massimo Pandolfo, Université Libre de Bruxelles (ULB), Brussels (Belgium), Jörg B. Schulz, University Hospital RWTH Aachen, (Germany), Paola Giunti University College London (London, UK), Alexandra Dürr, UPMC Université Paris (France), Mathieu Anheim, Hôpitaux niversitaires de Strasbourg
(France), Sylvia Boesch, Medical University Innsbruck (Austria), Caterina Mariotti, Fondazione
IRCCS Istituto Neurologico “C.Besta” (Italy), Enrico Bertini, Bambino Gesù Children’s Research Hospital (Italy), Francesc Palau, Pediatric Institute for Rare Diseases – IPER (Spain)
Research project grant

Award: £174,600

Funders: Ataxia UK, AFAF, Ataxia
Ireland, FEDAES, DHAG, AISA

 

Cerebellar ataxia

Project Principal Researchers & Institution Funders & Awards
Motor and cognitive outcomes of non-invasive transcranial alternate current stimulation by entrainment of cerebellar oscillations Dr Barbara Borroni, Department of Clinical and Experimental Sciences, University of Brescia, Brescia (Italy) Research project small grant

Award: £5,000

Funders: Ataxia UK

PROSPAX: an integrated multimodal progression chart in spastic ataxias
 
Professor Rita Horvath, Department of Clinical Neurosciences, University of Cambridge (UK) Research project small grant

Award: £5,000

Funders: Ataxia UK

Non-invasive transcranial cerebellar stimulation: double blind, randomised, sham-controlled study followed by an open label extension phase Dr Barbara Borroni, Department of Clinical and Experimental Sciences, University of Brescia, Brescia (Italy) Research project grant

Award: £25,000

Funders: Ataxia UK

Regulation of alternative splicing of voltage-gated Ca2+ channels by CRISPR/Cas9-mediated genome editing as potential genetic therapy for episodic ataxia type 2 Dr Lorenzo Cingolani, Center for Synaptic Neuroscience (NSYN), Fondazione Istituto Italiano di Tecnologia (IIT), Genoa (Italy) Research project small grant

Award: £5,000

Funders: Ataxia UK

Modelling SCA11 in cultured cells using CRISPR/Cas9 Dr Mariana Santos Moreda Graca, Institute for Molecular and Cell Biology (IBMC), Porto (Portugal) Research project small grant

Award: £5,000

Funders: Ataxia UK

Modelling the molecular pathogenesis of ARSACS with patient cells: disrupted proteostasis in ARSACS neurons Professor Paul Chapple,
Queen Mary University of London & Professor Michael Cheetham, University College London (London, UK)
Research project grant

Award: £70,000

Funders: Ataxia UK, The ARSACS Foundation

Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK Dr Clévio David Rodrigues Nóbrega, Universidade do Algarve (Portugal) Research project grant

Award: £9,500

Funders: Ataxia UK

DNA repair pathways underlie common genetic mechanisms that modulate onset in spinocerebellar ataxias and other inherited ataxias Dr Conceicao Bettencourt, Prof Henry Houlden, Prof Wood & Prof
Giunti, Institute of Neurology, University College London (London, UK)
PhD studentship grant

Award: £70,000

Funders: Ataxia UK, ACAH, R+SCAs, UCL Impact PhD Studentship Scheme

Development of a PRIME editing therapy for Ataxia-8 due to the c.121 A to T point mutation   

 

Prof Jacques Tremblay, Department of Molecular Medicine, Faculty of Medicine, Laval University (Canada) Research project grant

Award: £34,600

Funders: Ataxia UK and restricted donation from DVS foundation

Assessment of ataxia severity under real-life conditions with SARAhome: A multicenter study in spinocerebellar ataxia type 3 (SCA3)      Dr Marcus Grobe-Einsler and Prof Thomas Klockgether, German Center for Neurodegenerative Diseases (DZNE), Bonn (Germany)

 

 

Research project grant

Award: $80,000

Funders: Ataxia UK and NAF

A joint model of online SLT intervention and peer support to enhance communication effectiveness and participation in people with progressive ataxia     Prof Anja Lowit & Mrs Catherine McGee, Strathclyde University & NHS Greater Glasgow and Clyde (UK) Research project small grant

Award: £5,997

Funders: Ataxia UK

NKX6-2 Related Spastic Ataxia and Leukodystrophy: Natural history, biomarkers and the potential of gene transfer methods      

Dr Viorica Chelban and Prof Henry Houlden, UCL Institute of Neurology, Queen Square, London (UK)

Research project grant

Award: £69,988.29

Funders: Ataxia UK and restricted donation from DVS foundation

 

For information on Ataxia UK funded research that has ended in the last few years, click here.

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