Research funded by Ataxia UK
Ataxia UK is currently funding a wide variety of research projects. Here is a full list of current research projects.
Friedreich's ataxia research
- Neuron-validated Approaches for Developing Friedreich’s Ataxia Therapeutics
Principal Researchers: Dr Richard Wade-Martins, Dr Filip Lim*, Department of Physiology, Anatomy and Genetics, University of Oxford
- Restoration of Frataxin gene expression in Friedreich’s ataxia- identification and characterisation of novel epigenetic therapies
Principal researcher: Professor Richard Festenstein, Imperial College London
- Cannabinoid therapeutic testing of a Friedreich ataxia mouse model
Principal researcher: Dr Mark Pook, Brunel University.
- Epigenetic modifiers as potential disease modifying factors in Friedreich's ataxia.
Principal researcher: Dr R Festenstein, Imperial College (London)
See Scientific Conference presentation - An investigation into the relationship between rhythm and intonation in ataxic dysarthria
Principal researchers: Dr Anja Lowit and Dr Ineke Mennen, University of Strathclyde
- Understanding the role of frataxin in cell survival
Principal researcher: Dr Roberto Testi, University of Rome Tor Vergata, Italy.
This project is funded by Ataxia UK in collaboration with the US charity FARA.
Cerebellar ataxia research
- Understanding the role of interruptions in polyQ diseases
Researchers: Paola Giunti, Annalisa Pastore, University College London and National Institute for Medical Research, London
- Identification of a novel gene causing autosomal dominant ataxia and nystagmus
Principal Researcher: Nicola Ragge, University of Oxford
- DNA replication origin and triplet repeat instability in spinocerebellar ataxia type VII (SCA7)
Principal researchers: Dr Mauro Giacca and Dr Alessandro Carrer, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
- Evaluation of RNA trans-splicing therapy for spinocerebellar ataxia, type 1 – A pilot study
Principal researcher: Jean-Marc GALLO, Institute of Psychiatry, King’s College London.
- Development of high throughput genetic testing for cerebellar ataxias
Principal Researchers: Dr Andrea Nemeth, Dr Kevin Talbot, Dr Jenny Taylor, Dr Anneke Seller, John Radcliffe Hospital, Oxford.
- Developing non-invasive therapeutic technology to improve motor coordination in cerebellar ataxias
Principal researchers: Professor David Lee, Dr Benjaman Schögler Perception Movement Action Research Centre, the University of Edinburgh
- RNAi therapy for Spinocerebellar Ataxia
Principal researcher: Dr Matthew JA Wood, University of Oxford
- The Genetic and Functional Characterisation of Spinocerebellar Ataxia type 11 (SCA11)
Principal researchers: Dr Henry Houlden, Dr Paola Giunti and Professor Nicholas Wood, Institute of Neurology London
- Degenerative ataxias and the potential for stem cell neuroprotection
Principal researchers: Dr Wilkins and Professor Scolding, Institute of Clinical Neurosciences, University of Bristol.
- Regulation of voltage-gate calcium channels in ataxia
Principal researcher: Dr Jamie Weiss, The University of Sheffield.
- Investigations into the cellular function of ataxin-2 by the use of ssRNA aptamers
Principal researchers: Dr. Sylvia Krobitsch and Dr. Zoltán Konthur, Max Planck Institute for Molecular Genetics, Germany
- Cognitive effects of cerebellar disorder
Principal researchers: Professor Tim Griffiths, Professor Patrick Chinnery and Dr Tom Kelly, University of Newcastle
- Genetic and functional analysis of mutations in the potassium channel gene KCNC3 that causes SCA13 in UK patients with ataxia
Principal researchers: Professor Kay Davies, Dr Kevin Talbot and Dr Esther Becker, University of Oxford
Physiotherapy
- Disruption of balance in spinocerebellar ataxia: developing targeted therapies
Principal researchers: Dr Brian Day, Dr Paola Giunti and Dr Jon Marsden, Institute of Neurology London
- An investigation of the effect of Lycra pressure garments in the management of movement control problems caused by cerebellar ataxia
Principal researchers: Martin Watson, Kathryn Mares, Dr Margaret McArthur and Dr Paul Worth, University of East Anglia
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